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Durability and Outcome of Initial Antiretroviral Treatments Received during 2000-2005 by Patients in the Swiss HIV Cohort Study

Vo, Thi Tuyet Nhung ; Ledergerber, Bruno ; Keiser, Olivia ; Hirschel, Bernard ; Furrer, Hansjakob ; Battegay, Manuel ; Cavassini, Matthias ; Bernasconi, Enos ; Vernazza, Pietro ; Weber, Rainer

In: Journal of Infectious Diseases, 2008, vol. 197, no. 12, p. 1685-1694

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    Titre
    • Durability and Outcome of Initial Antiretroviral Treatments Received during 2000-2005 by Patients in the Swiss HIV Cohort Study
    Auteur
    • Vo, Thi Tuyet Nhung. VCHAP Project, Tropical Disease Hospital, Ho Chi Minh City, Vietnam
    • Ledergerber, Bruno. Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich
    • Keiser, Olivia. Institute of Social and Preventive Medicine, University of Bern, Berne
    • Hirschel, Bernard. Division of Infectious Diseases, University Hospital, Geneva
    • Furrer, Hansjakob. Division of Infectious Diseases, University Hospital, Berne
    • Battegay, Manuel. Division of Infectious Diseases, University Hospital, Basel
    • Cavassini, Matthias. Division of Infectious Diseases, University Hospital, Lausanne
    • Bernasconi, Enos. Ospedale Regionale, Lugano
    • Vernazza, Pietro. Division of Infectious Diseases, Cantonal Hospital, St. Gall, Switzerland
    • Weber, Rainer. Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Journal of Infectious Diseases, 2008, vol. 197, no. 12, p. 1685-1694. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:290199
    Summary
    Background. Little is known about time trends, predictors, and consequences of changes made to antiretroviral therapy (ART) regimens early after patients initially start treatment. Methods. We compared the incidence of, reasons for, and predictors of treatment change within 1 year after starting combination ART (cART), as well as virological and immunological outcomes at 1 year, among 1866 patients from the Swiss HIV Cohort Study who initiated cART during 2000-2001, 2002-2003, or 2004-2005. Results. The durability of initial regimens did not improve over time (P = .15): 48.8% of 625 patients during 2000-2001, 43.8% of 607 during 2002-2003, and 44.3% of 634 during 2004-2005 changed cART within 1 year; reasons for change included intolerance (51.1% of all patients), patient wish (15.4%), physician decision (14.8%), and virological failure (7.1%). An increased probability of treatment change was associated with larger CD4+ cell counts, larger human immunodeficiency virus type 1 (HIV-1) RNA loads, and receipt of regimens that contained stavudine or indinavir/ritonavir, but a decreased probability was associated with receipt of regimens that contained tenofovir. Treatment discontinuation was associated with larger CD4+ cell counts, current use of injection drugs, and receipt of regimens that contained nevirapine. One-year outcomes improved between 2000-2001 and 2004-2005: 84.5% and 92.7% of patients, respectively, reached HIV-1 RNA loads of <50 copies/mL and achieved median increases in CD4+ cell counts of 157.5 and 197.5 cells/µL, respectively (P < .001 for all comparisons). Conclusions. Virological and immunological outcomes of initial treatments improved between 2000-2001 and 2004-2005, irrespective of uniformly high rates of early changes in treatment across the 3 study intervals