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Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice

Müller, N. ; Imboden, M. ; Detmer, E. ; Mansfield, J. M. ; Seebeck, T.

In: Parasitology, 1993, vol. 107, no. 4, p. 411-417

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    Title
    • Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice
    Author
    • Müller, N.. Institut für Allgemeine Mikrobiologie, University of Bern, Baltzerstrasse 4, CH-3012 Bern, Switzerland
    • Imboden, M.. Institut für Allgemeine Mikrobiologie, University of Bern, Baltzerstrasse 4, CH-3012 Bern, Switzerland
    • Detmer, E.. Institut für Allgemeine Mikrobiologie, University of Bern, Baltzerstrasse 4, CH-3012 Bern, Switzerland
    • Mansfield, J. M.. Department of Animal Health and Biomedical Sciences, 1655 Linden Drive, University of Wisconsin, Madison, WI 53706, USA
    • Seebeck, T.. Institut für Allgemeine Mikrobiologie, University of Bern, Baltzerstrasse 4, CH-3012 Bern, Switzerland
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:289672
    Summary
    Serum from uninfected mice of different strains, as well as from germ-free animals, contains antibodies which react specifically with at least two trypanosomal proteins, I/6 and MARP1. These antibody populations are highly specific for the respective proteins, are of similar affinity as hyperimmune antibodies, and consist of IgM as well as IgG isotypes. Hyperimmune antibody raised against the cross-reacting trypanosomal protein I/6 detects a 60 kDa protein in mouse 3T6 cells, which is a component of the fibroblast cytoskeleton