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Auditory mismatch impairments are characterized by core neural dysfunctions in schizophrenia

Gaebler, Arnim Johannes ; Mathiak, Klaus ; Koten, Jan Willem ; König, Andrea Anna ; Koush, Yury ; Weyer, David ; Depner, Conny ; Matentzoglu, Simeon ; Edgar, James Christopher ; Willmes, Klaus ; Zvyagintsev, Mikhail

In: Brain, 2015, vol. 138, no. 5, p. 1410-1423

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    Titel
    • Auditory mismatch impairments are characterized by core neural dysfunctions in schizophrenia
    Autor
    • Gaebler, Arnim Johannes. 1 Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School, RWTH Aachen University, Aachen, Germany
    • Mathiak, Klaus. 1 Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School, RWTH Aachen University, Aachen, Germany
    • Koten, Jan Willem. 3 Neuropsychology Section, Department of Neurology, Medical School, RWTH Aachen University, Aachen, Germany
    • König, Andrea Anna. 1 Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School, RWTH Aachen University, Aachen, Germany
    • Koush, Yury. 5 Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland
    • Weyer, David. 7 Brain Imaging Facility, IZKF Aachen, RWTH Aachen University, Aachen, Germany
    • Depner, Conny. 8 Katharina Kasper Via Nobis GmbH, Hospital for Psychiatry and Psychotherapy, Gangelt, Germany
    • Matentzoglu, Simeon. 8 Katharina Kasper Via Nobis GmbH, Hospital for Psychiatry and Psychotherapy, Gangelt, Germany
    • Edgar, James Christopher. 9 Department of Radiology, Lurie Family Foundation MEG Imaging Centre, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
    • Willmes, Klaus. 3 Neuropsychology Section, Department of Neurology, Medical School, RWTH Aachen University, Aachen, Germany
    • Zvyagintsev, Mikhail. 1 Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School, RWTH Aachen University, Aachen, Germany
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Brain, 2015, vol. 138, no. 5, p. 1410-1423. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:289584
    Summary
    Reduced mismatch negativity is a well-established phenomenon in schizophrenia, but its underlying mechanisms are unclear. Using fMRI, Gaebler et al. reveal that auditory mismatch stimuli trigger multiple neural dysfunctions associated with schizophrenia. The fMRI response enables diagnostic separation of patients and controls with high accuracy, suggesting biomarker potential