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Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme

Eastmond, David A. ; Hartwig, Andrea ; Anderson, Diana ; Anwar, Wagida A. ; Cimino, Michael C. ; Dobrev, Ivan ; Douglas, George R. ; Nohmi, Takehiko ; Phillips, David H. ; Vickers, Carolyn

In: Mutagenesis, 2009, vol. 24, no. 4, p. 341-349

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    Titre
    • Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme
    Auteur
    • Eastmond, David A.. Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA
    • Hartwig, Andrea. Institut für Lebensmitteltechnologie und Lebensmittelchemie, Technische Universität Berlin, Berlin, Germany
    • Anderson, Diana. Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire, UK
    • Anwar, Wagida A.. Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Abassya, Cairo, Egypt
    • Cimino, Michael C.. Risk Assessment Division, Science Support Branch, Office of Pollution Prevention and Toxics, Environmental Protection Agency, Washington, DC, USA
    • Dobrev, Ivan. Department of Chemical Risk Assessment, Fraunhofer Institute for Toxicology and Experimental Medicine, Hanover, Germany
    • Douglas, George R.. Mechanistic Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
    • Nohmi, Takehiko. Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan
    • Phillips, David H.. Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, UK
    • Vickers, Carolyn. International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Mutagenesis, 2009, vol. 24, no. 4, p. 341-349. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:289426
    Summary
    Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of publications addressing test strategies for mutagenicity. Safety assessments of substances with regard to genotoxicity are generally based on a combination of tests to assess effects on three major end points of genetic damage associated with human disease: gene mutation, clastogenicity and aneuploidy. It is now clear from the results of international collaborative studies and the large databases that are currently available for the assays evaluated that no single assay can detect all genotoxic substances. The World Health Organization therefore decided to update the IPCS Harmonized Scheme for Mutagenicity Testing as part of the IPCS project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. The approach presented in this paper focuses on the identification of mutagens and genotoxic carcinogens. Selection of appropriate in vitro and in vivo tests as well as a strategy for germ cell testing are described