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First case of ivermectin-induced severe hepatitis

Veit, Olivia ; Beck, Bernhard ; Steuerwald, Michael ; Hatz, Christoph

In: Transactions of The Royal Society of Tropical Medicine and Hygiene, 2006, vol. 100, no. 8, p. 795-797

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    Titre
    • First case of ivermectin-induced severe hepatitis
    Auteur
    • Veit, Olivia. Swiss Tropical Institute, Medical Department, Socinstrasse 57, 4002 Basle, Switzerland
    • Beck, Bernhard. Swiss Tropical Institute, Medical Department, Socinstrasse 57, 4002 Basle, Switzerland
    • Steuerwald, Michael. University Hospital, Department of Gastroenterology & Hepatology, 4002 Basle, Switzerland
    • Hatz, Christoph. Swiss Tropical Institute, Medical Department, Socinstrasse 57, 4002 Basle, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Transactions of The Royal Society of Tropical Medicine and Hygiene, 2006, vol. 100, no. 8, p. 795-797. Royal Society of Tropical Medicine and Hygiene
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:289419
    Summary
    Loiasis, caused by the filarial parasite Loa loa, is endemic in West and Central Africa. Ivermectin has been shown to be an effective treatment of loiasis. We report the case of a 20-year-old woman originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin. Liver biopsy showed intralobular inflammatory infiltrates, confluent necrosis and apoptosis, compatible with drug-induced liver disease. To our knowledge, this is the first case of ivermectin-induced severe liver disease published in the literature