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Sero-epidemiological survey for alveolar echinococcosis (by Em2-ELISA) of blood donors in an endemic area of Switzerland

Gottstein, Bruno ; Lengeler, Christian ; Bachmann, Pierre ; Hagemann, Peter ; Kocher, Pierre ; Brossard, Michel ; Witassek, Felix ; Eckert, Johannes

In: Transactions of The Royal Society of Tropical Medicine and Hygiene, 1987, vol. 81, no. 6, p. 960-964

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    Titre
    • Sero-epidemiological survey for alveolar echinococcosis (by Em2-ELISA) of blood donors in an endemic area of Switzerland
    Auteur
    • Gottstein, Bruno. Institute of Parasitology, University of Zürich, CH-8057 Zürich, Switzerland
    • Lengeler, Christian. Institute of Zoology, University of Neuchâtel, CH-2000 Neuchâtel, Switzerland
    • Bachmann, Pierre. Central Laboratory, Blood Transfusion Service, Swiss Red Cross, CH-3000 Bern, Switzerland
    • Hagemann, Peter. Central Laboratory, Kantonsspital, CH-8596 Münsterlingen, Switzerland
    • Kocher, Pierre. Blood Transfusion Centre of La-Chaux-de-Fonds, CH-2300 La Chaux-de-Fonds, Switzerland
    • Brossard, Michel. Institute of Zoology, University of Neuchâtel, CH-2000 Neuchâtel, Switzerland
    • Witassek, Felix. Institute of Parasitology, University of Zürich, CH-8057 Zürich, Switzerland
    • Eckert, Johannes. Institute of Parasitology, University of Zürich, CH-8057 Zürich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Transactions of The Royal Society of Tropical Medicine and Hygiene, 1987, vol. 81, no. 6, p. 960-964. Royal Society of Tropical Medicine and Hygiene
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:289275
    Summary
    Sera from 17 166 blood donors living in 10 cantons of northern Switzerland in an area endemic for Echinococcus multilocularis were investigated by serological survey for alveolar echinococcosis (AE). A highly species-specific antigen (Em2) and a commonly used E. granulosus hydatid fluid antigen (EgHF) were compared for their suitability in seroepidemiology. EgHF showed a degree of nonspecificity which did not allow direct detection of AE cases. Antibody reaction with Em2 resulted in the detection of 2 asymptomatic clinical cases of AE (seroprevalence 0·01%) within this population of blood donors. A further 4 persons were positive in Em2-ELISA. These 4 persons had negative imaging studies and will be followed serologically and clinically