000028767 001__ 28767
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000028767 041__ $$aeng
000028767 080__ $$a57
000028767 100__ $$aChareyron, Loïc J.$$uLaboratory of Brain and Cognitive Development, Department of Medicine, University of Fribourg, Switzerland
000028767 245__ $$9eng$$aPostnatal development of the amygdala: A stereological study in macaque monkeys
000028767 269__ $$c2011-12-16
000028767 520__ $$9eng$$aAbnormal development of the amygdala has been linked to several neurodevelopmental disorders, including schizophrenia and autism. However, the postnatal development of the amygdala is not easily explored at the cellular level in humans. Here, we performed a stereological analysis of the macaque monkey amygdala in order to characterize the cellular changes underlying its normal structural development in primates. The lateral, basal and accessory basal nuclei exhibited the same developmental pattern, with a large increase in volume between birth and three months of age, followed by slower growth continuing beyond one year of age. In contrast, the medial nucleus was near adult size at birth. At birth, the volume of the central nucleus was half of the adult value; this nucleus exhibited significant growth even after one year of age. Neither neuronal soma size, nor neuron or astrocyte numbers changed during postnatal development. In contrast, oligodendrocyte numbers increased substantially, in parallel with an increase in amygdala volume, after three months of age. At birth, the paralaminar nucleus contained a large pool of immature neurons that gradually developed into mature neurons, leading to a late increase in the volume of this nucleus. Our findings revealed that distinct amygdala nuclei exhibit different developmental profiles and that the amygdala is not fully mature for some time postnatally. We identified different periods during which pathogenic factors might lead to the abnormal development of distinct amygdala circuits, which may contribute to different human neurodevelopmental disorders associated with alterations of amygdala structure and functions.
000028767 695__ $$9eng$$aamygdaloid complex ; emotion ; fear ; social behavior ; neurons ; astrocytes ; oligodendrocytes ; neuropil ; neurodevelopmental disorders ; anxiety ; autism ; schizophrenia
000028767 700__ $$aBanta Lavenex, Pamela A.$$uLaboratory of Brain and Cognitive Development, Department of Medicine, University of Fribourg, Switzerland
000028767 700__ $$aAmaral, David G.$$uDepartment of Psychiatry and Behavioral Sciences, Center for Neuroscience, California National Primate Research Center, The M.I.N.D. Institute, UC Davis, USA
000028767 700__ $$aLavenex, Pierre$$uLaboratory of Brain and Cognitive Development, Department of Medicine, University of Fribourg, Switzerland
000028767 773__ $$g2012///-$$tThe Journal of Comparative Neurology
000028767 775__ $$gPublished version$$ohttp://dx.doi.org/10.1002/cne.23023
000028767 8564_ $$flav_pda.pdf$$qapplication/pdf$$s1016344$$uhttps://doc.rero.ch/record/28767/files/lav_pda.pdf$$yorder:1$$zpdf
000028767 918__ $$aFaculté des sciences$$bDécanat, Ch. du Musée 6A, 1700 Fribourg$$cMédecine
000028767 919__ $$aUniversité de Fribourg$$bFribourg$$ddoc.support@rero.ch
000028767 980__ $$aPOSTPRINT$$bUNIFR$$fART_JOURNAL
000028767 990__ $$a20120315095808-ZM