000028498 001__ 28498
000028498 005__ 20130225122259.0
000028498 0248_ $$aoai:doc.rero.ch:20120210115644-AX$$ppostprint$$prero_explore$$zthesis_urn$$zreport$$zthesis$$zcdu370$$zbook$$zjournal$$zcdu16$$zpreprint$$zcdu1$$zdissertation$$zunine$$zcdu34
000028498 041__ $$aeng
000028498 080__ $$a370
000028498 100__ $$aPoulin, Stéphane$$uCentre de recherche Université Laval Robert-Giffard, G1J 2G3, Canada
000028498 245__ $$9eng$$aPsychogenic or neurogenic origin of agrammatism and foreign accent syndrome in a bipolar patient: a case report
000028498 269__ $$c2007
000028498 520__ $$9eng$$a<br> <b>Background</b> <br> Foreign accent syndrome (FAS) is a rare speech disorder characterized by the appearance of a new accent, different from the speaker's native language and perceived as foreign by the speaker and the listener. In most of the reported cases, FAS follows stroke but has also been found following traumatic brain injury, cerebral haemorrhage and multiple sclerosis. In very few cases, FAS was reported in patients presenting with psychiatric disorders but the link between this condition and FAS was confirmed in only one case.  <br> <b>Case presentation</b> <br> In this report, we present the case of FG, a bipolar patient presenting with language disorders characterized by a foreign accent and agrammatism, initially categorized as being of psychogenic origin. The patient had an extensive neuropsychological and language evaluation as well as brain imaging exams. In addition to FAS and agrammatism, FG also showed a working memory deficit and executive dysfunction. Moreover, these clinical signs were related to altered cerebral activity on an FDG-PET scan that showed diffuse hypometabolism in the frontal, parietal and temporal lobes bilaterally as well as a focal deficit in the area of the anterior left temporal lobe. When compared to the MRI, these deficits were related to asymmetric atrophy, which was retrospectively seen in the left temporal and frontal opercular/insular region without a focal lesion.  <br> <b>Discussion</b> <br> To our knowledge, FG is the first case of FAS imaged with an <sup>18</sup>F-FDG-PET scan. The nature and type of neuropsychological and linguistic deficits, supported by neuroimaging data, exclude a neurotoxic or neurodegenerative origin for this patient's clinical manifestations. For similar reasons, a psychogenic etiology is also highly improbable.  <br> <b>Conclusion</b> <br> To account for the FAS and agrammatism in FG, various explanations have been ruled out. Because of the focal deficit seen on the brain imaging, involving the left insular and anterior temporal cortex, two brain regions frequently involved in aphasic syndrome but also in FAS, a cerebrovascular origin must be considered the best explanation to account for FG's language deficits.
000028498 700__ $$aMacoir, Joël$$uUniversité Laval, Faculté de médecine, Pavillon Ferdinand-Vandry, Québec, (Qc) G1K 7P4, Canada
000028498 700__ $$aPaquet, Nancy$$uService de médecine nucléaire, rue Wolfe, Lévis (Qc) G6V 3Z1, Canada
000028498 700__ $$aFossard, Marion$$uInstitut des sciences du langage et de la communication, Chaire de logopédie II, Faculté des lettres et sciences humaines, Université de Neuchâtel, Switzerland
000028498 700__ $$aGagnon, Louis$$uService de médecine nucléaire, rue Wolfe, Lévis (Qc) G6V 3Z1, Canada
000028498 773__ $$dBioMed Central$$g2007/6/1/1-13$$tAnnals of General Psychiatry
000028498 775__ $$gPublished Version$$ohttp://dx.doi.org/10.1186/1744-859X-6-1
000028498 8564_ $$fPoulin_Stephane_-_Psychogenic_or_neurogenic_origin_of_agrammatism_20120210.pdf$$qapplication/pdf$$s1299768$$uhttp://doc.rero.ch/record/28498/files/Poulin_Stephane_-_Psychogenic_or_neurogenic_origin_of_agrammatism_20120210.pdf$$yorder:1$$zTexte intégral
000028498 918__ $$aFaculté des lettres et sciences humaines$$bEspace Louis-Agassiz 1, 2001 Neuchâtel$$cInstitut des sciences du langage et de la communication, Université de Neuchâtel
000028498 919__ $$aUniversité de Neuchâtel$$bNeuchâtel$$ddoc.support@rero.ch
000028498 980__ $$aPOSTPRINT$$bUNINE$$fART_JOURNAL
000028498 990__ $$a20120210115644-AX