Perfect timing: epigenetic regulation of the circadian clock
- Ripperger, Jürgen A. Department of Biology, Unit of Biochemistry, Faculty of Sciences, University of Fribourg, Switzerland
- Merrow, Martha Department of Molecular and Genetic Chronobiology, Faculty of Mathematics and Natural Sciences, University of Groningen, The Netherlands
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27.04.2011
Published in:
- FEBS Letters. - 2011, vol. 585, no. 10, p. 1406-1411
English
In mammals, higher order chromatin structures are critical for downsizing the genome (packaging) so that the nucleus can be small. The adjustable density of chromatin also regulates gene expression, thus this post-genetic molecular mechanism is one of the routes by which phenotype is shaped. Phenotypes that arise without a concomitant mutation of the underlying genome are termed epigenetic phenomena. Here we discuss epigenetic phenomena from histone and DNA modification as it pertains to the dynamic regulatory processes of the circadian clock. Epigenetic phenomena certainly explain some regulatory aspects of the mammalian circadian oscillator.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Biologie
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 22467
- DOI 10.1016/j.febslet.2011.04.047
- Persistent URL
- https://folia.unifr.ch/unifr/documents/301869
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