Faculté des sciences

The difficult-to-control spread of carbapenemase producers in Enterobacteriaceae worldwide

Nordmann, Patrice ; Poirel, Laurent

In: Clinical Microbiology and Infection, 2014, p. -

Spread of carbapenemase producers in Enterobacteriaceae is now identified worldwide. Three main carbapenemases are reported which belong to three classes of ß-lactamases that are KPC, NDM and OXA-48. The main reservoirs of KPC are Klebsiella pneumoniae in the USA, Israel, Greece and Italy, of NDM are K. pneumoniae and Escherichia coli in the Indian subcontinent, and of OXA-48 are K. pneumoniae... More

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    Summary
    Spread of carbapenemase producers in Enterobacteriaceae is now identified worldwide. Three main carbapenemases are reported which belong to three classes of ß-lactamases that are KPC, NDM and OXA-48. The main reservoirs of KPC are Klebsiella pneumoniae in the USA, Israel, Greece and Italy, of NDM are K. pneumoniae and Escherichia coli in the Indian subcontinent, and of OXA-48 are K. pneumoniae and E. coli in North Africa and Turkey. KPC producers remain mostly identified in nosocomial isolates whereas NDM and OXA-48 producers are both nosocomial and community-acquired pathogens. Control of their spread is still possible in hospital settings and relies on the use of rapid diagnostic techniques and strict implemention of hygiene measures.