Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons
- Manseau, Frédéric European Brain Research Institute, Rome, Italy
- Marinelli, Silvia European Brain Research Institute, Rome, Italy
- Méndez, Pablo European Brain Research Institute, Rome, Italy
- Schwaller, Beat Unit of Anatomy, Department of Medicine, University of Fribourg, Switzerland
- Prince, David A. Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, USA
- Huguenard, John R. Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, USA
- Bacci, Alberto European Brain Research Institute, Rome, Italy
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28.09.2010
Published in:
- PLoS Biology. - 2010, vol. 8, no. 9, p. e1000492
English
Networks of specific inhibitory interneurons regulate principal cell firing in several forms of neocortical activity. Fast-spiking (FS) interneurons are potently self-inhibited by GABAergic autaptic transmission, allowing them to precisely control their own firing dynamics and timing. Here we show that in FS interneurons, high-frequency trains of action potentials can generate a delayed and prolonged GABAergic self-inhibition due to sustained asynchronous release at FS-cell autapses. Asynchronous release of GABA is simultaneously recorded in connected pyramidal (P) neurons. Asynchronous and synchronous autaptic release show differential presynaptic Ca²⁺ sensitivity, suggesting that they rely on different Ca²⁺ sensors and/or involve distinct pools of vesicles. In addition, asynchronous release is modulated by the endogenous Ca²⁺ buffer parvalbumin. Functionally, asynchronous release decreases FS-cell spike reliability and reduces the ability of P neurons to integrate incoming stimuli into precise firing. Since each FS cell contacts many P neurons, asynchronous release from a single interneuron may desynchronize a large portion of the local network and disrupt cortical information processing.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 21007
- DOI 10.1371/journal.pbio.1000492
- Persistent URL
- https://folia.unifr.ch/unifr/documents/301763
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