Faculté des sciences

Exit-strategies – smart ways to release phospholipid vesicle cargo

Mellal, Denia ; Zumbuehl, Andreas

In: Journal of Materials Chemistry B, 2014, vol. 2, no. 3, p. 247–252

This highlight describes recent trends in fundamental phospholipid research towards possible future drug delivery technology. In particular it focuses on synthetic phospholipids and their vesicular constructs and describes selected “smart” ways to release cargo from liposomes. Various chemical and physical release triggers are discussed such as temperature changes, application of ultrasound,... More

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    Summary
    This highlight describes recent trends in fundamental phospholipid research towards possible future drug delivery technology. In particular it focuses on synthetic phospholipids and their vesicular constructs and describes selected “smart” ways to release cargo from liposomes. Various chemical and physical release triggers are discussed such as temperature changes, application of ultrasound, enzyme degradation, changes in pH, redox reactions, photochemical reactions, as well as the effects of shear stress on vesicles.