Dissemination of carbapenemase-producing Enterobacteriaceae in France, 2012
- Dortet, Laurent INSERM U914 ‘Emerging Resistance to Antibiotics’, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, K.-Bicêtre, France - Associated National Reference Center for Antibiotic Resistance, K.-Bicêtre, France
- Cuzon, Gaëlle INSERM U914 ‘Emerging Resistance to Antibiotics’, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, K.-Bicêtre, France
- Nordmann, Patrice INSERM U914 ‘Emerging Resistance to Antibiotics’, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, K.-Bicêtre, France - Associated National Reference Center for Antibiotic Resistance, K.-Bicêtre, France - Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland
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03.01.2014
Published in:
- Journal of Antimicrobial Chemotherapy. - 2014, vol. 69, no. 3, p. 623-627
English
Objectives: Carbapenem-resistant Enterobacteriaceae isolates (n = 1485) were received at the French Associated National Reference Center for Antibiotic Resistance in 2012 and were characterized for their mechanism of resistance to carbapenems.Methods: Carbapenemase production was detected using the biochemical-based Carba NP test, based on the detection of in vitro hydrolysis of imipenem. All isolates with a positive Carba NP test result were characterized by PCR and sequencing.Results: Carbapenemase production was identified in 23.1% of the isolates. The main carbapenemase type identified was OXA-48 and derivatives (75.5%). An overseas source was clearly demonstrated for only 27.6% of the isolates.Conclusions: OXA-48 and derivatives are now the most prevalent carbapenemases in France, with a possible spread of these producers in the community
- Faculty
- Faculté des sciences et de médecine
- Department
- Médecine 3ème année
- Language
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- English
- Classification
- Medicine
- License
- License undefined
- Identifiers
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- RERO DOC 209483
- DOI 10.1093/jac/dkt433
- Persistent URL
- https://folia.unifr.ch/unifr/documents/303331
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