Neuroendocrine characterization and anorexigenic effects of telmisartan in diet- and glitazone-induced weight gain
- Aubert, Gregory Service of Endocrinology, Diabetology and Metabolism, Department of Medicine, Lausanne CHUV, Switzerland
- Burnier, Michel Service of Nephrology, Department of Medicine, Lausanne CHUV, Switzerland
- Dulloo, Abdul G. Division of Physiology, University of Fribourg, Switzerland
- Perregaux, Christine Service of Nephrology, Department of Medicine, Lausanne CHUV, Switzerland
- Mazzolai, Lucia Service of Vascular Medicine, Department of Medicine, Lausanne CHUV, Switzerland
- Pralong, François Service of Endocrinology, Diabetology and Metabolism, Department of Medicine, Lausanne CHUV, Switzerland
- Zanchi, Anne Service of Nephrology, Department of Medicine, Lausanne CHUV, Switzerland
-
30.09.2009
Published in:
- Metabolism - Clinical and Experimental. - 2010, vol. 59, no. 1, p. 25-32
English
Telmisartan is an angiotensin II receptor blocker with peroxisome proliferator–activated receptor–γ agonistic properties. Telmisartan prevents weight gain and decreases food intake in models of obesity and in glitazone-treated rodents. This study further investigates the influence of telmisartan and pioglitazone and their association on weight gain and body composition by examining their influence on neuroendocrine mediators involved in food intake. Male C57/Black 6 mice were fed a high-fat diet, weight matched, and randomized in 4 treatment groups: vehicle, pioglitazone, telmisartan, and pioglitazone-telmisartan. Weight gain, food and water intake, body composition, plasma leptin levels, and the hypothalamic expression of neuroendocrine mediators were analyzed. Additional studies were performed with irbesartan and in angiotensin II 1A receptor–knockout mice. Telmisartan abolished weight and fat gain in vehicle- and pioglitazone-treated mice while decreasing food intake, the hypothalamic expression of the agouti-related protein, and plasma leptin levels. Modifications in neuropeptide Y and proopiomelanocortin were not consistent with changes in food intake. The effects on weight gain and expression of the agouti-related protein were intermediate with irbesartan. The effects of telmisartan on weight gain were even more pronounced in angiotensin II 1A receptor–knockout mice. This study confirms the anorexigenic effects of telmisartan in mice fed a high-fat diet and suggests for the first time a functional role of telmisartan on hypothalamic orexigenic agouti-related protein regulation. These anorexigenic properties abolish both weight gain and body composition modifications in fat-fed and glitazone-treated mice. The anorexigenic properties are independent from the angiotensin II 1A receptor.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
-
- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
-
- RERO DOC 17282
- DOI 10.1016/j.metabol.2009.07.002
- Persistent URL
- https://folia.unifr.ch/unifr/documents/301443
Statistics
Document views: 35
File downloads:
- dulloo_nca.pdf: 60