Faculté des sciences

Towards a planar sample support for in situ experiments in structural biology

Gullo, M. R. ; Akiyama, Terunobu ; Frederix, P. L. T. M. ; Tonin, A. ; Staufer, Urs ; Engel, A. ; de Rooij, Nicolaas F.

In: Microelectronic Engineering, 2005, vol. 78-79, p. 571-574

We report about the development of a planar support for biological samples. The aim is to combine AFM and patch-clamp measurements, in order to perform simultaneous measurements of topography and electrical properties of biological membranes. Sub-micrometer apertures have been fabricated using standard MEMS techniques. The electrical quality of the support has been experimentally assessed. Plus

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    Summary
    We report about the development of a planar support for biological samples. The aim is to combine AFM and patch-clamp measurements, in order to perform simultaneous measurements of topography and electrical properties of biological membranes. Sub-micrometer apertures have been fabricated using standard MEMS techniques. The electrical quality of the support has been experimentally assessed.