Faculté des sciences

Bafoudiosbulbins F and G, further clerodane diterpenoids from Dioscorea bulbifera L. var sativa and revised structure of Bafoudiosbulbin B

Teponno, Rémy Bertrand ; Tapondjou, Azefack Léon ; Abou-Mansour, Eliane ; Stoeckli-Evans, Helen ; Tane, Pierre ; Barboni, Luciano

In: Phytochemistry, 2008, vol. 69, no. 12, p. 2374-2379

From the bulbils of Dioscorea bulbifera L. var sativa, two clerodane diterpenoids, Bafoudiosbulbins F (1) and G (2), together with five known compounds: Bafoudiosbulbins A–C, 3,5,4′-trihydroxy-3′-methoxybibenzyl, and kaempferol were isolated. Their structures were established by spectroscopic techniques, including 1H,13C NMR, NOESY, ROESY,... Plus

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    Summary
    From the bulbils of Dioscorea bulbifera L. var sativa, two clerodane diterpenoids, Bafoudiosbulbins F (1) and G (2), together with five known compounds: Bafoudiosbulbins A–C, 3,5,4′-trihydroxy-3′-methoxybibenzyl, and kaempferol were isolated. Their structures were established by spectroscopic techniques, including 1H,13C NMR, NOESY, ROESY, COSY, TOCSY, HSQC, and HMBC. The relative stereochemistry of compounds 1 and 2 was assigned on the basis of X-ray crystallographic diffraction analysis. Furthermore, the structure of Bafoudiosbulbin B was revised using extensive 2D NMR techniques as well as chemical transformation.