Caffeine extends yeast lifespan by targeting TORC1
- Wanke, Valeria Department of Microbiology and Molecular Medicine, University of Geneva Medical School, Switzerland.
- Cameroni, Elisabetta Department of Microbiology and Molecular Medicine, University of Geneva Medical School, Switzerland. - Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland.
- Uotila, Aino Department of Molecular Biology, University of Geneva, Switzerland.
- Piccolis, Manuele Department of Molecular Biology, University of Geneva, Switzerland.
- Urban, Jörg Department of Molecular Biology, University of Geneva, Switzerland.
- Loewith, Robbie Department of Molecular Biology, University of Geneva, Switzerland.
- De Virgilio, Claudio Department of Microbiology and Molecular Medicine, University of Geneva Medical School, Switzerland. - Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland.
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28.06.2008
Published in:
- Molecular Microbiology. - 2008, vol. 69, no. 1, p. 277 - 285
English
Dietary nutrient limitation (dietary restriction) is known to increase lifespan in a variety of organisms. Although the molecular events that couple dietary restriction to increased lifespan are not clear, studies of the model eukaryote Saccharomyces cerevisiae have implicated several nutrient-sensitive kinases, including the target of rapamycin complex 1 (TORC1), Sch9, protein kinase A (PKA) and Rim15. We have recently demonstrated that TORC1 activates Sch9 by direct phosphorylation. We now show that Sch9 inhibits Rim15 also by direct phosphorylation. Treatment of yeast cells with the specific TORC1 inhibitor rapamycin or caffeine releases Rim15 from TORC1-Sch9-mediated inhibition and consequently increases lifespan. This kinase cascade appears to have been evolutionarily conserved, suggesting that caffeine may extend lifespan in other eukaryotes, including man.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Biologie
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 10556
- DOI 10.1111/j.1365-2958.2008.06292.x
- Persistent URL
- https://folia.unifr.ch/unifr/documents/300849
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